Gastro-protective Effect of Corn Diet against Indomethacin Induced Ulceration in Experimental Rats

Introduction: One of the most prevalent gastrointestinal ailments is gastric ulcer, which caused by an imbalance between protective and aggressive factors. Zea mays Corn a significant cereal crop containing natural phytochemical substances that are sources nourishment. The methanolic extract Corn, according to previous study, lowers stomach acidity inhibits percentage ulceration with no knowledge on mechanisms involved.
 Aim: This study investigated underlying gastroprotective diet (ZD).
 Materials Methods: Sixty male Wistar rats were used, randomly grouped into 6; 1(Normal control), 2(Ulcerated 3, 4, 5 (prefed ZD -55%, 65%, 75%) 6 (cimetidine- 25mg/kg) for 28 days. Gastric ulcer was induced oral administration indomethacin (40mg/kg) animals sacrificed after 4 hours. excised cleaned, it then homogenized centrifuged biochemical assays.
 Results: There reduction in area all treated groups. Significant increase tissue mucin content mucosal SOD, NO PGE2 levels MDA observed cimetidine group. Histological evaluation showed tubular glands closely packed separated from each other laminar propia, however there mild presence inflammatory cells within propia groups compared ulcerated control group moderate oedema infiltration vascular congestion mucosa. macroscopic lesions inhibition 90%, 92%, 90% 92% (55%, 65% respectively.
 Conclusion: Results obtained this suggests Zm may have anti-ulcerogenic properties enhancing antioxidant enzymes as well as, nitric oxide prostaglandin E2 mechanisms.